Jason Chan
Assistant Professor of Biology

(317) 955-6458
Marian Hall, Room 063


Jason Chan, Assistant Professor of Biology, joined Marian in 2019. He received his Ph.D. in Neuroscience from Tufts University School of Medicine (MA) studying adult neurogenesis and affective behavior, completed postdoctoral research at the University of Southern California (CA) studying proteins involved in synaptic function. Jason also brings previous experience teaching physiology, cell and molecular biology, neuroscience, and introductory biology labs. Currently, his research focuses on identifying the underlying biology of how animals age, and how to prolong healthy aging.


  • Ph.D. Neuroscience, Tufts University School of Medicine (Boston, MA)
  • B.A. Neuroscience and Behavior, Wesleyan University (Middletown, CT)

Professional affiliations

  • Genetics Society of America (GSA)
  • American Society of Biochemistry and Molecular Biology (ASBMB)
  • American Society of Cell Biology (ASCB)
  • Faculty for Undergraduate Neuroscience (FUN)


  • BIO 204/L Cell Biology and Cell Biology Lab
  • BIO 205 Statistical Analysis and Experimental Design for Biologists
  • BIO 305 Neurobiology

Research interests/portfolio

  • Identifying cell signaling factors that mediate animal aging and healthspan (healthy aging)
  • Examining lipid signaling and metabolism in animals
  • Studying how bacteria and hosts communicate with each other, such as in the gut
  • Using model organisms, such as C. elegans (roundworm), to understand human biology


*Signifies undergraduate scholars

  • Chan JP, Wright JR, Wong HT, Ardasheva A, Brumbaugh J, McLimans C, Lamendella R. (2019) Using Bacterial Transcriptomics to Investigate Targets of Host-Bacterial Interactions in Caenorhabditis elegans. Sci Rep. Apr 3;9(1):5545. doi: 10.1038/s41598-019-41452-2.
  • Brabec JL*, Vos MR*, Staab TA, Chan JP. (2018) Analysis of Student Attitudes of a Neurobiology Themed Inquiry Based Research Experience in First Year Biology Labs. J Undergrad Neurosci Educ. 2018 Dec 15;17(1):A1-A9.
  • Chan JP, Brown J*, Hark B*, Nolan A*, Servello D*, Hrobuchak H*, Staab TA. (2017) Loss of Sphingosine Kinase Alters Life History Traits and Locomotor Function in Caenorhabditis elegans. Front Genet. Sep 21;8:132. doi: 10.3389/fgene.2017.00132.
  • Shen H, Giordano F, Wu Y, Chan J, Zhu C, Milosevic I, Wu X, Yao K, Chen B, Baumgart T, Sieburth D, De Camilli P. (2014) Coupling between endocytosis and sphingosine kinase 1 recruitment. Nat Cell Biol. 2014 Jul;16(7):652-62. doi: 10.1038/ncb2987
  • Chan JP, Staab TA, Wang H, Mazzasette C, Butte Z*, Sieburth D. (2013) Extrasynaptic muscarinic acetylcholine receptors on neuronal cell bodies regulate presynaptic function in Caenorhabditis elegans. J Neurosci. Aug 28;33(35):14146-59. doi: 10.1523/JNEUROSCI.1359-13.2013
  • Wang H, Girskis K*, Janssen T, Chan JP, Dasgupta K, Knowles JA, Schoofs L, Sieburth D. (2013) Neuropeptide secreted from a pacemaker activates neurons to control a rhythmic behavior. Curr Biol. May 6;23(9):746-54. doi: 10.1016/j.cub.2013.03.049
  • Chan JP, Sieburth D. (2012) Localized sphingolipid signaling at presynaptic terminals is regulated by calcium influx and promotes recruitment of priming factors. J Neurosci. Dec 5;32(49):17909-20. doi: 10.1523/JNEUROSCI.2808-12.2012
  • Chan JP, Hu Z, Sieburth D. (2012) Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release. Genes Dev. May 15;26(10):1070-85. doi: 10.1101/gad.188003.112

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